Assay Detail
Binding
CHEMBL3606412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R mutant (unknown origin) expressed in Sf9 cells by enzyme kinetics assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.70 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604943 | — | — | 1 | 8.80 |
| CHEMBL3545308 | ROCILETINIB | 3.0 | 1 | 8.76 |
| CHEMBL3604921 | — | — | 1 | 7.15 |
| CHEMBL3604937 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604943 | — | Ki | = | 1.58 | nM | 8.80 |
| CHEMBL3545308 | ROCILETINIB | Ki | = | 1.75 | nM | 8.76 |
| CHEMBL3604921 | — | Ki | = | 70.2 | nM | 7.15 |
| CHEMBL3604937 | — | Ki | = | 833.0 | nM | 6.08 |