Assay Detail
Binding
CHEMBL3606413
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in Sf9 cells by enzyme kinetics assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.08 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604937 | — | — | 1 | 9.49 |
| CHEMBL3604921 | — | — | 1 | 9.19 |
| CHEMBL3604943 | — | — | 1 | 8.84 |
| CHEMBL3545308 | ROCILETINIB | 3.0 | 1 | 8.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604937 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL3604921 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL3604943 | — | Ki | = | 1.46 | nM | 8.84 |
| CHEMBL3545308 | ROCILETINIB | Ki | = | 1.65 | nM | 8.78 |