Assay Detail
Functional
CHEMBL3606515
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 LAI infected in human MT2 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.99 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605635 | — | — | 1 | 9.47 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.52 |
| CHEMBL3605641 | — | — | 1 | 8.43 |
| CHEMBL3605640 | — | — | 1 | 8.36 |
| CHEMBL3605638 | — | — | 1 | 8.36 |
| CHEMBL3605636 | — | — | 1 | 8.36 |
| CHEMBL3605637 | — | — | 1 | 8.14 |
| CHEMBL3605646 | — | — | 1 | 7.66 |
| CHEMBL3605643 | — | — | 1 | 7.46 |
| CHEMBL3605642 | — | — | 1 | 7.43 |
| CHEMBL3605639 | — | — | 1 | 7.32 |
| CHEMBL3605644 | — | — | 1 | 6.32 |
| CHEMBL3605645 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605635 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL1323 | DARUNAVIR | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3605641 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3605640 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3605638 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3605636 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3605637 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL3605646 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3605643 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3605642 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3605639 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3605644 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3605645 | — | IC50 | - | — | - |