Assay Detail
Functional
CHEMBL3606519
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against darunavir-resistant HIV1 P51 infected in human MT4 cells by XTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.23 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605646 | — | — | 1 | 6.64 |
| CHEMBL3605635 | — | — | 1 | 6.58 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 5.46 |
| CHEMBL3605643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605646 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3605635 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3605643 | — | EC50 | - | — | - |