Assay Detail
Binding
CHEMBL3606685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cathepsin-K using Z-Gly-Pro-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.67 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371064 | BALICATIB | 2.0 | 1 | 8.85 |
| CHEMBL3605410 | — | — | 1 | 8.00 |
| CHEMBL3605409 | — | — | 1 | 7.80 |
| CHEMBL3605413 | — | — | 1 | 7.66 |
| CHEMBL3605414 | — | — | 1 | 7.26 |
| CHEMBL3605408 | — | — | 1 | 7.16 |
| CHEMBL3605412 | — | — | 1 | 6.94 |
| CHEMBL3605411 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371064 | BALICATIB | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL3605410 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3605409 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3605413 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3605414 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL3605408 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL3605412 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL3605411 | — | Ki | > | 500.0 | nM | - |