Assay Detail
Binding
CHEMBL3606696
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HDAC3/NCOR2 (unknown origin) pre-incubated for 3 hrs before substrate addition by homogeneous fluorogenic HDAC assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (CHEMBL2111363) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.50 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605506 | — | — | 1 | 8.22 |
| CHEMBL3605502 | — | — | 1 | 7.96 |
| CHEMBL3605415 | — | — | 1 | 7.82 |
| CHEMBL3605508 | — | — | 1 | 7.75 |
| CHEMBL3605499 | — | — | 1 | 7.75 |
| CHEMBL3605507 | — | — | 1 | 7.68 |
| CHEMBL3605497 | — | — | 1 | 7.62 |
| CHEMBL3605500 | — | — | 1 | 7.51 |
| CHEMBL3605495 | — | — | 1 | 7.48 |
| CHEMBL3605498 | — | — | 1 | 7.47 |
| CHEMBL3605496 | — | — | 1 | 7.47 |
| CHEMBL3605503 | — | — | 1 | 7.46 |
| CHEMBL3605416 | — | — | 1 | 7.42 |
| CHEMBL3605494 | — | — | 1 | 7.40 |
| CHEMBL3605501 | — | — | 1 | 7.39 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 7.35 |
| CHEMBL3605504 | — | — | 1 | 7.26 |
| CHEMBL3605492 | — | — | 1 | 7.25 |
| CHEMBL3605417 | — | — | 1 | 7.18 |
| CHEMBL3605493 | — | — | 1 | 7.15 |
| CHEMBL3605505 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605506 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3605502 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3605415 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3605508 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3605499 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3605507 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3605497 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3605500 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3605495 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3605498 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3605496 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3605503 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3605416 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3605494 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3605501 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL272980 | MOCETINOSTAT | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3605504 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3605492 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3605417 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3605493 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3605505 | — | IC50 | = | 120.0 | nM | 6.92 |