Assay Detail
Binding
CHEMBL3606937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Escherichia coli MTAN expressed in Escherichia coli BL-21 DE3 using methylthioadenosine as substrate by xanthine oxidase coupling enzyme assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (CHEMBL1250346) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli O157:H7 |
Publication
Tight binding enantiomers of pre-clinical drug candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.34 | 10.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405346 | — | — | 1 | 10.32 |
| CHEMBL3604360 | — | — | 1 | 8.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405346 | — | Ki | = | 0.048 | nM | 10.32 |
| CHEMBL3604360 | — | Ki | = | 4.5 | nM | 8.35 |