Assay Detail
Binding
CHEMBL3607094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.66 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518383 | — | — | 1 | 7.52 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 7.33 |
| CHEMBL457388 | — | — | 1 | 6.85 |
| CHEMBL456163 | — | — | 1 | 6.07 |
| CHEMBL508964 | — | — | 1 | 5.52 |
| CHEMBL86795 | INDAZOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518383 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL445813 | AT-7519 | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL457388 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL456163 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL508964 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL86795 | INDAZOLE | IC50 | = | 185000.0 | nM | - |