Assay Detail
Functional
CHEMBL3607098
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar blue assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.49 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 7.10 |
| CHEMBL457388 | — | — | 1 | 6.52 |
| CHEMBL518383 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445813 | AT-7519 | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL457388 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL518383 | — | IC50 | = | 1400.0 | nM | 5.85 |