Assay Detail
Binding
CHEMBL3607152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE4D
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.78 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77826 | — | — | 1 | 8.82 |
| CHEMBL3605513 | — | — | 1 | 8.52 |
| CHEMBL3605510 | — | — | 1 | 8.10 |
| CHEMBL3605511 | — | — | 1 | 7.89 |
| CHEMBL2172370 | — | — | 1 | 7.72 |
| CHEMBL3605512 | — | — | 1 | 7.66 |
| CHEMBL3605509 | — | — | 1 | 7.52 |
| CHEMBL2172374 | — | — | 1 | 7.50 |
| CHEMBL2172375 | — | — | 1 | 7.39 |
| CHEMBL2172368 | — | — | 1 | 7.29 |
| CHEMBL2172372 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77826 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3605513 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3605510 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3605511 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2172370 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3605512 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3605509 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2172374 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2172375 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2172368 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2172372 | — | IC50 | = | 64.0 | nM | 7.19 |