Assay Detail
Binding
CHEMBL3607245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human C-terminal DNMT3A after 1 hr by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA (cytosine-5)-methyltransferase 3A (CHEMBL1992) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of new non nucleoside inhibitors of DNMT3A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.66 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336409 | — | — | 1 | 6.05 |
| CHEMBL3605964 | — | — | 1 | 5.68 |
| CHEMBL3605935 | — | — | 1 | 5.52 |
| CHEMBL3605951 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336409 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3605964 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3605935 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3605951 | — | EC50 | = | 4000.0 | nM | 5.40 |