Assay Detail
Functional
CHEMBL3607253
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Antiproliferative activity against human KG1 cells after 2 to 4 days by ATPlite 1step luminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KG-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of new non nucleoside inhibitors of DNMT3A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.93 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66115 | DOXECITINE | 2.0 | 1 | 7.00 |
| CHEMBL3605961 | — | — | 1 | 5.43 |
| CHEMBL2336409 | — | — | 1 | 5.36 |
| CHEMBL3605960 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66115 | DOXECITINE | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3605961 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2336409 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3605960 | — | EC50 | > | 10000.0 | nM | - |