Assay Detail
Functional
CHEMBL3607254
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KARPAS299 cells after 2 to 4 days by ATPlite 1step luminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KARPAS-299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of new non nucleoside inhibitors of DNMT3A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.75 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336409 | — | — | 1 | 5.75 |
| CHEMBL3605960 | — | — | 1 | - |
| CHEMBL3605961 | — | — | 1 | - |
| CHEMBL66115 | DOXECITINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336409 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3605960 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3605961 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL66115 | DOXECITINE | EC50 | > | - | nM | - |