Assay Detail
Functional
CHEMBL3607330
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Cytotoxicity against human LNCAP cells after 7 days by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.03 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50588 | EMETINE | 4.0 | 1 | 7.43 |
| CHEMBL2171637 | — | — | 1 | 7.10 |
| CHEMBL2171638 | — | — | 1 | 5.88 |
| CHEMBL3605301 | — | — | 1 | 5.80 |
| CHEMBL3605306 | — | — | 1 | 5.78 |
| CHEMBL3605304 | — | — | 1 | 5.77 |
| CHEMBL3605302 | — | — | 1 | 5.75 |
| CHEMBL3605305 | — | — | 1 | 5.71 |
| CHEMBL3605307 | — | — | 1 | 5.64 |
| CHEMBL3605303 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50588 | EMETINE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2171637 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL2171638 | — | IC50 | = | 1312.0 | nM | 5.88 |
| CHEMBL3605301 | — | IC50 | = | 1592.0 | nM | 5.80 |
| CHEMBL3605306 | — | IC50 | = | 1656.0 | nM | 5.78 |
| CHEMBL3605304 | — | IC50 | = | 1698.0 | nM | 5.77 |
| CHEMBL3605302 | — | IC50 | = | 1763.0 | nM | 5.75 |
| CHEMBL3605305 | — | IC50 | = | 1951.0 | nM | 5.71 |
| CHEMBL3605307 | — | IC50 | = | 2303.0 | nM | 5.64 |
| CHEMBL3605303 | — | IC50 | = | 3390.0 | nM | 5.47 |