Assay Detail
ADMET
CHEMBL3607580
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Cytotoxicity against CHO cells by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.06 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50588 | EMETINE | 4.0 | 1 | 6.98 |
| CHEMBL2058036 | — | — | 1 | 5.31 |
| CHEMBL3604381 | — | — | 1 | 5.20 |
| CHEMBL3604376 | — | — | 1 | 5.12 |
| CHEMBL3604382 | — | — | 1 | 5.12 |
| CHEMBL3604377 | — | — | 1 | 4.98 |
| CHEMBL3604380 | — | — | 1 | 4.94 |
| CHEMBL3604383 | — | — | 1 | 4.90 |
| CHEMBL3604379 | — | — | 1 | 4.86 |
| CHEMBL3604385 | — | — | 1 | 4.73 |
| CHEMBL3604384 | — | — | 1 | 4.59 |
| CHEMBL3604393 | — | — | 1 | 4.54 |
| CHEMBL3604375 | — | — | 1 | 4.53 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
| CHEMBL3604378 | — | — | 1 | - |
| CHEMBL3604386 | — | — | 1 | - |
| CHEMBL3604387 | — | — | 1 | - |
| CHEMBL3604388 | — | — | 1 | - |
| CHEMBL3604389 | — | — | 1 | - |
| CHEMBL3604390 | — | — | 1 | - |
| CHEMBL682 | AMODIAQUINE | 4.0 | 1 | - |
| CHEMBL3604396 | — | — | 1 | - |
| CHEMBL3604395 | — | — | 1 | - |
| CHEMBL3604394 | — | — | 1 | - |
| CHEMBL3604392 | — | — | 1 | - |
| CHEMBL2058035 | — | — | 1 | - |
| CHEMBL3604391 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50588 | EMETINE | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL2058036 | — | IC50 | = | 4903.0 | nM | 5.31 |
| CHEMBL3604381 | — | IC50 | = | 6369.0 | nM | 5.20 |
| CHEMBL3604376 | — | IC50 | = | 7584.0 | nM | 5.12 |
| CHEMBL3604382 | — | IC50 | = | 7594.0 | nM | 5.12 |
| CHEMBL3604377 | — | IC50 | = | 10552.0 | nM | 4.98 |
| CHEMBL3604380 | — | IC50 | = | 11466.0 | nM | 4.94 |
| CHEMBL3604383 | — | IC50 | = | 12630.0 | nM | 4.90 |
| CHEMBL3604379 | — | IC50 | = | 13701.0 | nM | 4.86 |
| CHEMBL3604385 | — | IC50 | = | 18769.0 | nM | 4.73 |
| CHEMBL3604384 | — | IC50 | = | 25729.0 | nM | 4.59 |
| CHEMBL3604393 | — | IC50 | = | 28732.0 | nM | 4.54 |
| CHEMBL3604375 | — | IC50 | = | 29593.0 | nM | 4.53 |
| CHEMBL76 | CHLOROQUINE | IC50 | - | — | - | |
| CHEMBL3604378 | — | IC50 | = | 124086.0 | nM | - |
| CHEMBL3604386 | — | IC50 | > | 240000.0 | nM | - |
| CHEMBL3604387 | — | IC50 | > | 240000.0 | nM | - |
| CHEMBL3604388 | — | IC50 | = | 164240.0 | nM | - |
| CHEMBL3604389 | — | IC50 | > | 240000.0 | nM | - |
| CHEMBL3604390 | — | IC50 | = | 122285.0 | nM | - |
| CHEMBL682 | AMODIAQUINE | IC50 | = | 147157.0 | nM | - |
| CHEMBL3604396 | — | IC50 | - | — | - | |
| CHEMBL3604395 | — | IC50 | - | — | - | |
| CHEMBL3604394 | — | IC50 | = | 172111.0 | nM | - |
| CHEMBL3604392 | — | IC50 | > | 240000.0 | nM | - |
| CHEMBL2058035 | — | IC50 | - | — | - | |
| CHEMBL3604391 | — | IC50 | = | 229255.0 | nM | - |