Assay Detail
Functional
CHEMBL3607775
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Antiproliferative activity against p53 deficient human Saos2 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SAOS-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.82 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601317 | — | — | 1 | 4.92 |
| CHEMBL3604658 | — | — | 1 | 4.71 |
| CHEMBL3601318 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601317 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3604658 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL3601318 | — | IC50 | > | 30000.0 | nM | - |