Assay Detail

CHEMBL3607801

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET

Inhibition of CYP2B6 in human liver microsomes after 20 mins by LC-MS/MS analysis

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Cytochrome P450 2B6 (CHEMBL4729) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Cytochrome P450 2B6 (CHEMBL4729) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cytochrome P450 2B6

CHEMBL4729

Anchored from Assay target.

Protein identity Cytochrome P450 2B6

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Tissue	Liver
Subcellular	Microsomes
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cytochrome P450 2B6 (CHEMBL4729) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy.

Papeo G, Posteri H, Borghi D, Busel AA, Caprera F, Casale E, Ciomei M, Cirla A, Corti E, D'Anello M, Fasolini M, Forte B, Galvani A, Isacchi A, Khvat A, Krasavin MY, Lupi R, Orsini P, Perego R, Pesenti E, Pezzetta D, Rainoldi S, Riccardi-Sirtori F, Scolaro A, Sola F, Zuccotto F, Felder ER, Donati D, Montagnoli A.
J Med Chem (2015) 58 : 6875 -6898
PubMed 26222319 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.09	5.09

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3606021	—	—	1	5.09

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3606021	—	IC50	=	8150.0	nM	5.09