Cytochrome P450 2B6 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P20813. Use UniProt P20813 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P20813 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 2B6
Review this target as Cytochrome P450 2B6, mapped to UniProt P20813. Sequence length is 491 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 2B6 as ChEMBL target CHEMBL4729, mapped to UniProt P20813. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cytochrome P450 2B6 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P20813 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 2B6 |
| UniProt Accession | P20813 |
| Component Type | Protein |
| Sequence Length | 491 aa |
Cytochrome P450 2B6
Review this target as Cytochrome P450 2B6, mapped to UniProt P20813. Sequence length is 491 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4175869 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL4160749 | 7.21 | IC50 | 62.0 | Preclinical |
| CHEMBL4168669 | 7.14 | IC50 | 73.0 | Preclinical |
| CHEMBL4165249 | 7.06 | IC50 | 87.0 | Preclinical |
| CHEMBL4161819 | 7.03 | IC50 | 93.0 | Preclinical |
| CHEMBL4161400 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL4159065 | 6.75 | IC50 | 180.0 | Preclinical |
| CHEMBL833 | 6.7 | Ki | 200.0 | Approved |
| CHEMBL833 | 6.68 | IC50 | 210.0 | Approved |
| CHEMBL4169324 | 6.64 | IC50 | 230.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 313 | 119 | 4.9 |
| microsome format | 153 | 109 | 5.2 |
| assay format | 70 | 11 | 5.0 |
| cell-based format | 70 | 7 | 5.8 |
| tissue-based format | 8 | 0 | — |
| cell membrane format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 2 | 5.2 |
| assay format | 2 | 9 | 4.6 |
| tissue-based format | 2 | 1 | 4.7 |