Assay Detail
Binding
CHEMBL3607998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of androgen receptor in human LNCAP cells assessed as inhibition of DHT-induced SPDEF gene expression by Array Plate assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent 17β-Hydroxywithanolides for Castration-Resistant Prostate Cancer by High-Throughput Screening of a Natural Products Library for Androgen-Induced Gene Expression Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.77 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605564 | — | — | 1 | 6.11 |
| CHEMBL3605563 | — | — | 1 | 5.92 |
| CHEMBL3605562 | — | — | 1 | 5.57 |
| CHEMBL3605560 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605564 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3605563 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3605562 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL3605560 | — | IC50 | = | 3280.0 | nM | 5.48 |