Assay Detail
Binding
CHEMBL3608050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic acid substrate addition by HPLC-UV spectroscopy
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL2903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 60 | 6.51 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604156 | — | — | 1 | 9.00 |
| CHEMBL3604185 | — | — | 1 | 8.70 |
| CHEMBL3604184 | — | — | 1 | 8.40 |
| CHEMBL3604180 | — | — | 1 | 7.70 |
| CHEMBL3604138 | — | — | 1 | 7.58 |
| CHEMBL3604153 | — | — | 1 | 7.50 |
| CHEMBL3604152 | — | — | 1 | 7.15 |
| CHEMBL3604132 | — | — | 1 | 7.09 |
| CHEMBL3604151 | — | — | 1 | 7.07 |
| CHEMBL3604174 | — | — | 1 | 7.00 |
| CHEMBL3604158 | — | — | 1 | 6.82 |
| CHEMBL3604134 | — | — | 1 | 6.78 |
| CHEMBL3604141 | — | — | 1 | 6.75 |
| CHEMBL3604131 | — | — | 1 | 6.75 |
| CHEMBL3604157 | — | — | 1 | 6.74 |
| CHEMBL3604155 | — | — | 1 | 6.54 |
| CHEMBL3604140 | — | — | 1 | 6.48 |
| CHEMBL3604139 | — | — | 1 | 6.42 |
| CHEMBL3604147 | — | — | 1 | 6.42 |
| CHEMBL3604181 | — | — | 1 | 6.35 |
| CHEMBL3604133 | — | — | 1 | 6.35 |
| CHEMBL3604146 | — | — | 1 | 6.34 |
| CHEMBL3604137 | — | — | 1 | 6.26 |
| CHEMBL3604173 | — | — | 1 | 6.24 |
| CHEMBL3604166 | — | — | 1 | 6.19 |
| CHEMBL1587607 | — | — | 1 | 6.19 |
| CHEMBL3604145 | — | — | 1 | 6.17 |
| CHEMBL3604143 | — | — | 1 | 6.07 |
| CHEMBL3604171 | — | — | 1 | 6.02 |
| CHEMBL3604142 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604156 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3604185 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3604184 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3604180 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3604138 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3604153 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3604152 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3604132 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3604151 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3604174 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3604158 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3604134 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL3604131 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3604141 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3604157 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL3604155 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3604140 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL3604139 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL3604147 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL3604181 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL3604133 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL3604146 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL3604137 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3604173 | — | IC50 | = | 571.0 | nM | 6.24 |
| CHEMBL1587607 | — | IC50 | = | 645.0 | nM | 6.19 |
| CHEMBL3604166 | — | IC50 | = | 641.0 | nM | 6.19 |
| CHEMBL3604145 | — | IC50 | = | 672.0 | nM | 6.17 |
| CHEMBL3604143 | — | IC50 | = | 843.0 | nM | 6.07 |
| CHEMBL3604171 | — | IC50 | = | 947.0 | nM | 6.02 |
| CHEMBL3604142 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL3604160 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3604135 | — | IC50 | = | 1207.0 | nM | 5.92 |
| CHEMBL3604177 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3604179 | — | IC50 | = | 3273.0 | nM | 5.49 |
| CHEMBL3604176 | — | IC50 | = | 3965.0 | nM | 5.40 |
| CHEMBL3603844 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3604167 | — | IC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL3604172 | — | IC50 | = | 6976.0 | nM | 5.16 |
| CHEMBL3604175 | — | IC50 | = | 22530.0 | nM | 4.65 |
| CHEMBL3604136 | — | IC50 | - | — | - | |
| CHEMBL3604170 | — | IC50 | - | — | - | |
| CHEMBL3604178 | — | IC50 | - | — | - | |
| CHEMBL3604182 | — | IC50 | - | — | - | |
| CHEMBL3604183 | — | IC50 | - | — | - | |
| CHEMBL3604154 | — | IC50 | - | — | - | |
| CHEMBL3604150 | — | IC50 | - | — | - | |
| CHEMBL3604149 | — | IC50 | - | — | - | |
| CHEMBL3604148 | — | IC50 | - | — | - | |
| CHEMBL3604144 | — | IC50 | - | — | - | |
| CHEMBL3604129 | — | IC50 | - | — | - |