Assay Detail
Binding
CHEMBL3608052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic acid substrate addition by HPLC-UV spectroscopy
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | L1236 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL2903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 6.70 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604156 | — | — | 1 | 8.00 |
| CHEMBL3604180 | — | — | 1 | 7.89 |
| CHEMBL3604153 | — | — | 1 | 7.85 |
| CHEMBL3604152 | — | — | 1 | 7.66 |
| CHEMBL3604132 | — | — | 1 | 7.62 |
| CHEMBL3604158 | — | — | 1 | 7.57 |
| CHEMBL3604151 | — | — | 1 | 7.48 |
| CHEMBL3604185 | — | — | 1 | 7.47 |
| CHEMBL3604162 | — | — | 1 | 7.43 |
| CHEMBL3604155 | — | — | 1 | 7.41 |
| CHEMBL3604164 | — | — | 1 | 7.41 |
| CHEMBL3604149 | — | — | 1 | 7.38 |
| CHEMBL3604154 | — | — | 1 | 7.38 |
| CHEMBL3604138 | — | — | 1 | 7.37 |
| CHEMBL445420 | — | — | 1 | 7.33 |
| CHEMBL3604174 | — | — | 1 | 7.25 |
| CHEMBL3604173 | — | — | 1 | 7.17 |
| CHEMBL3604166 | — | — | 1 | 7.16 |
| CHEMBL3604175 | — | — | 1 | 7.10 |
| CHEMBL3604141 | — | — | 1 | 7.04 |
| CHEMBL3604134 | — | — | 1 | 7.03 |
| CHEMBL3604170 | — | — | 1 | 7.01 |
| CHEMBL3604160 | — | — | 1 | 6.95 |
| CHEMBL3604137 | — | — | 1 | 6.93 |
| CHEMBL3604159 | — | — | 1 | 6.93 |
| CHEMBL3604181 | — | — | 1 | 6.91 |
| CHEMBL3604139 | — | — | 1 | 6.89 |
| CHEMBL3604184 | — | — | 1 | 6.88 |
| CHEMBL3604146 | — | — | 1 | 6.74 |
| CHEMBL3604163 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604156 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3604180 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3604153 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3604152 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3604132 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3604158 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3604151 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3604185 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3604162 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3604155 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3604164 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3604149 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3604154 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3604138 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL445420 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3604174 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3604173 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3604166 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3604175 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3604141 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3604134 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3604170 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL3604160 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL3604137 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL3604159 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3604181 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL3604139 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3604184 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL3604146 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL3604163 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL3604130 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3604161 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL3604167 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL3604172 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL3604143 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL3604133 | — | IC50 | = | 519.0 | nM | 6.29 |
| CHEMBL3604157 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL3604178 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL3603844 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL1587607 | — | IC50 | = | 618.0 | nM | 6.21 |
| CHEMBL3604179 | — | IC50 | = | 638.0 | nM | 6.20 |
| CHEMBL3604182 | — | IC50 | = | 716.0 | nM | 6.14 |
| CHEMBL3604147 | — | IC50 | = | 757.0 | nM | 6.12 |
| CHEMBL3604142 | — | IC50 | = | 837.0 | nM | 6.08 |
| CHEMBL3604148 | — | IC50 | = | 855.0 | nM | 6.07 |
| CHEMBL3604177 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3604145 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL3604131 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3604171 | — | IC50 | = | 2426.0 | nM | 5.62 |
| CHEMBL3604176 | — | IC50 | = | 3110.0 | nM | 5.51 |