Assay Detail
Binding
CHEMBL3608059
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Inhibition of rat 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic acid substrate addition by HPLC-UV spectroscopy
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.62 | 4.62 |
| Imax | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604174 | — | — | 2 | 4.62 |
| CHEMBL3604137 | — | — | 1 | - |
| CHEMBL3604140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604174 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3604137 | — | IC50 | - | — | - | |
| CHEMBL3604140 | — | IC50 | - | — | - | |
| CHEMBL3604174 | — | Imax | = | 79.0 | % | - |