Arachidonate 12-lipoxygenase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt Q02759. Use UniProt Q02759 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q02759 as the stable identity anchor, then attach disease evidence before program review.
Polyunsaturated fatty acid lipoxygenase ALOX15
Review this target as Arachidonate 12-lipoxygenase, mapped to UniProt Q02759. ChEMBL maps the protein component as Polyunsaturated fatty acid lipoxygenase ALOX15. Sequence length is 663 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Arachidonate 12-lipoxygenase as ChEMBL target CHEMBL2741, mapped to UniProt Q02759. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Arachidonate 12-lipoxygenase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q02759 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Polyunsaturated fatty acid lipoxygenase ALOX15 |
| UniProt Accession | Q02759 |
| Component Type | Protein |
| Sequence Length | 663 aa |
Polyunsaturated fatty acid lipoxygenase ALOX15
Review this target as Arachidonate 12-lipoxygenase, mapped to UniProt Q02759. ChEMBL maps the protein component as Polyunsaturated fatty acid lipoxygenase ALOX15. Sequence length is 663 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL37081 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL8260 | 7.82 | IC50 | 15.0 | Clinical |
| CHEMBL38168 | 7.48 | IC50 | 33.0 | Preclinical |
| CHEMBL37154 | 7.29 | IC50 | 51.0 | Preclinical |
| CHEMBL35934 | 7.28 | IC50 | 53.0 | Preclinical |
| CHEMBL37141 | 7.2 | IC50 | 63.0 | Preclinical |
| CHEMBL37180 | 7.19 | IC50 | 64.0 | Preclinical |
| CHEMBL36376 | 6.75 | IC50 | 180.0 | Preclinical |
| CHEMBL301253 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL55053 | 6.4 | IC50 | 400.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 10 | 24 | 5.6 |
| cell-based format | 1 | 1 | 4.6 |
| cell-free format | 1 | 10 | 7.2 |