Assay Detail
Binding
CHEMBL3608114
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Displacement of [3H]-sulpiride from human dopamine D3 receptor expressed in HEK293 cells after 150 mins by liquid scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of arylpiperazine-reverse amides as biased dopamine D3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.83 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605331 | — | — | 1 | 8.41 |
| CHEMBL3605344 | — | — | 1 | 8.03 |
| CHEMBL3605327 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605331 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL3605344 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL3605327 | — | Ki | = | 87.6 | nM | 7.06 |