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Compound Detail

CHEMBL3605327

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Cl.O=C(CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)Nc1nc2ccccc2s1

Basic Information

ChEMBL ID CHEMBL3605327
Phase Preclinical
Structure Type MOL
InChI Key UOVWQDUPAVHBNH-UHFFFAOYSA-N
Parent Compound CHEMBL3605326
Active Moiety CHEMBL3605326
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

463.4
MW (Da)
5.53
ALogP
5
HBA
1
HBD
48.5
PSA (Ų)
0.47
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H25Cl3N4OS
MW 499.89
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness -2.31

Activity Summary

Ki 4 meas. best 7.06

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(3) dopamine receptor
CHEMBL234
Ki 7.06 7.06 87.6 2
D(2) dopamine receptor
CHEMBL217
Ki 5.25 5.25 5586.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26278029 10.1016/j.bmc.2015.07.072 D(3) dopamine receptor 2
26278029 10.1016/j.bmc.2015.07.072 D(2) dopamine receptor 2
26278029 10.1016/j.bmc.2015.07.072 Unchecked 1
30288220 10.1039/C8MD00237A Unchecked 1
30288220 10.1039/C8MD00237A D(2) dopamine receptor 1
30288220 10.1039/C8MD00237A D(3) dopamine receptor 1

Data from ChEMBL 36 via Core Engine