Assay Detail
Binding
CHEMBL4259825
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-sulpiride from human D2 receptor expressed in HEK293 cells after 150 mins by liquid scintillation counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of bitopic arylpiperazine-phthalimides as selective dopamine D<sub>3</sub> receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.09 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605331 | — | — | 1 | 6.76 |
| CHEMBL4285942 | — | — | 1 | 6.69 |
| CHEMBL4294744 | — | — | 1 | 5.67 |
| CHEMBL3605327 | — | — | 1 | 5.25 |
| CHEMBL4287055 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605331 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL4285942 | — | Ki | = | 202.3 | nM | 6.69 |
| CHEMBL4294744 | — | Ki | = | 2163.1 | nM | 5.67 |
| CHEMBL3605327 | — | Ki | = | 5586.0 | nM | 5.25 |
| CHEMBL4287055 | — | Ki | > | 23889.0 | nM | - |