Assay Detail
Binding
CHEMBL3608168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by luminescence based luciferase assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Eukaryotic translation initiation factor 4E (CHEMBL5636) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.58 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604542 | — | — | 1 | 6.25 |
| CHEMBL3604540 | — | — | 1 | 5.91 |
| CHEMBL4299205 | — | — | 1 | 5.89 |
| CHEMBL3604543 | — | — | 1 | 5.89 |
| CHEMBL3604541 | — | — | 1 | 5.58 |
| CHEMBL4299204 | — | — | 1 | 5.49 |
| CHEMBL4299198 | — | — | 1 | 5.49 |
| CHEMBL4299199 | — | — | 1 | 5.49 |
| CHEMBL1094973 | — | — | 1 | 5.24 |
| CHEMBL3351000 | — | — | 1 | 4.60 |
| CHEMBL3604555 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604542 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3604540 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4299205 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL3604543 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3604541 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL4299204 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL4299198 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL4299199 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL1094973 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL3351000 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3604555 | — | IC50 | - | — | - |