Assay Detail
Binding
CHEMBL3609987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R/T790M double mutant in human H1975 cells assessed as inhibition of phosphorylation at Y1068 after 2 hrs by sandwich ELISA method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H1975 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of the Epidermal Growth Factor Receptor (EGFR) May Provide Effective Treatment for Lung Adenocarcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.34 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3608434 | — | — | 1 | 8.22 |
| CHEMBL3608433 | — | — | 1 | 8.22 |
| CHEMBL3608429 | — | — | 1 | 8.15 |
| CHEMBL3608430 | — | — | 1 | 7.85 |
| CHEMBL3608431 | — | — | 1 | 6.41 |
| CHEMBL3608432 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3608434 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3608433 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3608429 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3608430 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3608431 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL3608432 | — | IC50 | = | 6138.0 | nM | 5.21 |