Assay Detail
Binding
CHEMBL3609989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R mutant in human H3255 cells assessed as inhibition of phosphorylation at Y1068 after 2 hrs by sandwich ELISA method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H3255 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of the Epidermal Growth Factor Receptor (EGFR) May Provide Effective Treatment for Lung Adenocarcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.39 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3608429 | — | — | 1 | 8.70 |
| CHEMBL3608434 | — | — | 1 | 8.70 |
| CHEMBL3608433 | — | — | 1 | 8.30 |
| CHEMBL3608431 | — | — | 1 | 8.15 |
| CHEMBL3608430 | — | — | 1 | 8.10 |
| CHEMBL3608432 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3608429 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3608434 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3608433 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3608431 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3608430 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3608432 | — | IC50 | - | — | - |