Assay Detail
Binding
CHEMBL3610070
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Binding affinity to human recombinant NK3R by radioligand binding assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.31 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3422009 | — | — | 1 | 8.70 |
| CHEMBL3422018 | — | — | 1 | 8.50 |
| CHEMBL3608688 | — | — | 1 | 8.10 |
| CHEMBL3422010 | — | — | 1 | 7.90 |
| CHEMBL3608687 | — | — | 1 | 7.70 |
| CHEMBL3608683 | — | — | 1 | 7.60 |
| CHEMBL3608680 | FEZOLINETANT | 4.0 | 1 | 7.60 |
| CHEMBL3608741 | — | — | 1 | 7.50 |
| CHEMBL3608740 | — | — | 1 | 7.30 |
| CHEMBL3608684 | — | — | 1 | 7.00 |
| CHEMBL3608682 | — | — | 1 | 6.90 |
| CHEMBL3608686 | — | — | 1 | 6.70 |
| CHEMBL3608685 | — | — | 1 | 5.90 |
| CHEMBL3608681 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3422009 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL3422018 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL3608688 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL3422010 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL3608687 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL3608683 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3608680 | FEZOLINETANT | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3608741 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL3608740 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL3608684 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3608682 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL3608686 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL3608685 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL3608681 | — | Ki | = | 10000.0 | nM | 5.00 |