Assay Detail
Binding
CHEMBL3610107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to rat NK3R
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.72 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3422018 | — | — | 1 | 7.66 |
| CHEMBL3422010 | — | — | 1 | 7.12 |
| CHEMBL3608688 | — | — | 1 | 7.07 |
| CHEMBL3608680 | FEZOLINETANT | 4.0 | 1 | 6.66 |
| CHEMBL3608741 | — | — | 1 | 6.61 |
| CHEMBL3608740 | — | — | 1 | 6.24 |
| CHEMBL3608684 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3422018 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3422010 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL3608688 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL3608680 | FEZOLINETANT | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL3608741 | — | Ki | = | 244.0 | nM | 6.61 |
| CHEMBL3608740 | — | Ki | = | 573.0 | nM | 6.24 |
| CHEMBL3608684 | — | Ki | = | 2033.0 | nM | 5.69 |