Assay Detail
Binding
CHEMBL3610255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Sprague-Dawley rat lense aldose reductase using DL-glyceraldehyde as substrate by spectrofluorometric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.02 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3608478 | — | — | 1 | 5.42 |
| CHEMBL3608477 | — | — | 1 | 5.25 |
| CHEMBL3608476 | — | — | 1 | 4.86 |
| CHEMBL80679 | — | — | 1 | 4.54 |
| CHEMBL466534 | HUAZHONGILEXIN | — | 1 | - |
| CHEMBL3608479 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3608478 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3608477 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3608476 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL80679 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL466534 | HUAZHONGILEXIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608479 | — | IC50 | > | 100000.0 | nM | - |