Assay Detail
ADMET
CHEMBL3611296
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Cytotoxicity against chinese hamster V79 cells assessed as cell viability after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetulus griseus |
| Cell Type | V79 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hybrid compounds with two redox centres: modular synthesis of chalcogen-containing lapachones and studies on their antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.53 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.55 |
| CHEMBL3609563 | — | — | 1 | 5.66 |
| CHEMBL3609554 | — | — | 1 | 5.65 |
| CHEMBL3609556 | — | — | 1 | 5.65 |
| CHEMBL3609560 | — | — | 1 | 5.62 |
| CHEMBL3609552 | — | — | 1 | 5.59 |
| CHEMBL3609562 | — | — | 1 | 5.59 |
| CHEMBL3609557 | — | — | 1 | 5.51 |
| CHEMBL3609559 | — | — | 1 | 5.33 |
| CHEMBL3609555 | — | — | 1 | 5.28 |
| CHEMBL3609558 | — | — | 1 | 5.27 |
| CHEMBL3609561 | — | — | 1 | 5.25 |
| CHEMBL3609553 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3609563 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL3609554 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL3609556 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL3609560 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL3609552 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL3609562 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL3609557 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL3609559 | — | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL3609555 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL3609558 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL3609561 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL3609553 | — | IC50 | = | 10110.0 | nM | 5.00 |