Assay Detail
ADMET
CHEMBL3611297
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Cytotoxicity against mouse L929 cells assessed as cell viability after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hybrid compounds with two redox centres: modular synthesis of chalcogen-containing lapachones and studies on their antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.56 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.64 |
| CHEMBL3609556 | — | — | 1 | 5.82 |
| CHEMBL3609554 | — | — | 1 | 5.72 |
| CHEMBL3609563 | — | — | 1 | 5.72 |
| CHEMBL3609552 | — | — | 1 | 5.60 |
| CHEMBL3609562 | — | — | 1 | 5.53 |
| CHEMBL3609560 | — | — | 1 | 5.49 |
| CHEMBL3609559 | — | — | 1 | 5.46 |
| CHEMBL3609557 | — | — | 1 | 5.43 |
| CHEMBL3609558 | — | — | 1 | 5.33 |
| CHEMBL3609561 | — | — | 1 | 5.33 |
| CHEMBL3609555 | — | — | 1 | 5.24 |
| CHEMBL3609553 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3609556 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL3609554 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL3609563 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL3609552 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL3609562 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL3609560 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL3609559 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL3609557 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL3609558 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL3609561 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL3609555 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL3609553 | — | IC50 | = | 10470.0 | nM | 4.98 |