Assay Detail
Functional
CHEMBL3611368
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Increase in coronary flow in Wistar rat Langendorff isolated perfused heart
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Heart |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.48 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3609819 | — | — | 1 | 8.15 |
| CHEMBL3608316 | — | — | 1 | 7.80 |
| CHEMBL3609822 | — | — | 1 | 7.70 |
| CHEMBL3608941 | — | — | 1 | 7.70 |
| CHEMBL3609818 | — | — | 1 | 7.66 |
| CHEMBL3609824 | — | — | 1 | 7.64 |
| CHEMBL45816 | MIBEFRADIL | 4.0 | 1 | 7.58 |
| CHEMBL3608947 | — | — | 2 | 7.58 |
| CHEMBL3609817 | — | — | 1 | 7.58 |
| CHEMBL3609825 | — | — | 1 | 7.54 |
| CHEMBL3608943 | — | — | 1 | 7.42 |
| CHEMBL3608940 | — | — | 1 | 7.40 |
| CHEMBL3608945 | — | — | 2 | 7.38 |
| CHEMBL3608946 | — | — | 1 | 7.11 |
| CHEMBL3608942 | — | — | 1 | 6.87 |
| CHEMBL3608944 | — | — | 1 | 6.60 |
| CHEMBL3609821 | — | — | 1 | - |
| CHEMBL3609820 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3609819 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3608316 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3609822 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3608941 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3609818 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3609824 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL45816 | MIBEFRADIL | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3608947 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3609817 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3609825 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3608943 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3608947 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3608940 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3608945 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3608946 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3608942 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL3608944 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3609821 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL3608945 | — | EC50 | > | 150.0 | nM | - |
| CHEMBL3609820 | — | EC50 | > | 300.0 | nM | - |