Assay Detail
Binding
CHEMBL3611508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DAMGO from rat mu opioid receptor transfected in HN9.10 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.36 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3608939 | — | — | 1 | 10.30 |
| CHEMBL3609615 | — | — | 1 | 9.70 |
| CHEMBL3609620 | — | — | 1 | 9.52 |
| CHEMBL3609621 | — | — | 1 | 8.62 |
| CHEMBL3609618 | — | — | 1 | 8.49 |
| CHEMBL3608937 | — | — | 1 | 7.96 |
| CHEMBL3608938 | — | — | 1 | 7.48 |
| CHEMBL3609616 | — | — | 1 | 7.43 |
| CHEMBL3609617 | — | — | 1 | 7.31 |
| CHEMBL3609619 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3608939 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL3609615 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3609620 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3609621 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL3609618 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL3608937 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3608938 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL3609616 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL3609617 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL3609619 | — | Ki | = | 180.0 | nM | 6.75 |