Assay Detail
Binding
CHEMBL3611619
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human Kv1.1 expressed in HEK293 cells assessed as inhibition of potassium currents by automated patchXpress planar patch clamp electrophysiology assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily A member 1 (CHEMBL2309) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.39 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3609093 | — | — | 1 | 10.06 |
| CHEMBL3609095 | — | — | 1 | 9.67 |
| CHEMBL3609073 | — | — | 1 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3609093 | — | IC50 | = | 0.087 | nM | 10.06 |
| CHEMBL3609095 | — | IC50 | = | 0.214 | nM | 9.67 |
| CHEMBL3609073 | — | IC50 | = | 3.677 | nM | 8.44 |