Assay Detail
Binding
CHEMBL3611626
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Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.34 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3608938 | — | — | 1 | 8.22 |
| CHEMBL3608939 | — | — | 1 | 8.02 |
| CHEMBL3608937 | — | — | 1 | 7.89 |
| CHEMBL3609615 | — | — | 1 | 7.48 |
| CHEMBL3609621 | — | — | 1 | 7.39 |
| CHEMBL3609616 | — | — | 1 | 7.37 |
| CHEMBL3609618 | — | — | 1 | 6.75 |
| CHEMBL3609617 | — | — | 1 | 6.52 |
| CHEMBL3609620 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3608938 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3608939 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL3608937 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3609615 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3609621 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3609616 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3609618 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3609617 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3609620 | — | IC50 | = | 400.0 | nM | 6.40 |