Assay Detail
Binding
CHEMBL3611633
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Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contraction
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.55 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3608939 | — | — | 1 | 7.22 |
| CHEMBL3609615 | — | — | 1 | 6.92 |
| CHEMBL3609621 | — | — | 1 | 6.92 |
| CHEMBL3609618 | — | — | 1 | 6.68 |
| CHEMBL3608937 | — | — | 1 | 6.37 |
| CHEMBL3609616 | — | — | 1 | 6.28 |
| CHEMBL3609617 | — | — | 1 | 6.08 |
| CHEMBL3608938 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3608939 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3609615 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3609621 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3609618 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3608937 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3609616 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3609617 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL3608938 | — | IC50 | = | 1100.0 | nM | 5.96 |