Assay Detail
Binding
CHEMBL3611840
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Displacement of [3H]prazosin from alpha1B adrenoceptor in rat liver membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indolylpiperidine derivatives as potent and selective α1B adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.09 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3609360 | — | — | 1 | 9.21 |
| CHEMBL3609359 | — | — | 1 | 8.68 |
| CHEMBL1188811 | — | — | 1 | 8.52 |
| CHEMBL3609357 | — | — | 1 | 8.44 |
| CHEMBL3609353 | — | — | 1 | 8.32 |
| CHEMBL3609358 | — | — | 1 | 8.15 |
| CHEMBL3609354 | — | — | 1 | 8.14 |
| CHEMBL3609356 | — | — | 1 | 8.12 |
| CHEMBL3609355 | — | — | 1 | 7.96 |
| CHEMBL3609351 | — | — | 1 | 7.89 |
| CHEMBL3609352 | — | — | 1 | 7.33 |
| CHEMBL15988 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3609360 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL3609359 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL1188811 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3609357 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL3609353 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL3609358 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL3609354 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL3609356 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL3609355 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3609351 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL3609352 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL15988 | — | Ki | = | 440.0 | nM | 6.36 |