Assay Detail
ADMET
CHEMBL3614243
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Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by Alamar blue assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.27 | 4.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3612338 | — | — | 1 | 4.54 |
| CHEMBL3612343 | — | — | 1 | 4.44 |
| CHEMBL3612341 | — | — | 1 | 4.35 |
| CHEMBL3612346 | — | — | 1 | 4.21 |
| CHEMBL3612344 | — | — | 1 | 4.17 |
| CHEMBL3612339 | — | — | 1 | 4.16 |
| CHEMBL3612337 | — | — | 1 | 4.04 |
| CHEMBL3612340 | — | — | 1 | - |
| CHEMBL3410622 | — | — | 1 | - |
| CHEMBL3612342 | — | — | 1 | - |
| CHEMBL3612345 | — | — | 1 | - |
| CHEMBL3612347 | — | — | 1 | - |
| CHEMBL3612837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3612338 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3612343 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3612341 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL3612346 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL3612344 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL3612339 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL3612337 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL3612340 | — | IC50 | = | 137000.0 | nM | - |
| CHEMBL3410622 | — | IC50 | = | 126000.0 | nM | - |
| CHEMBL3612342 | — | IC50 | = | 169000.0 | nM | - |
| CHEMBL3612345 | — | IC50 | = | 114000.0 | nM | - |
| CHEMBL3612347 | — | IC50 | = | 127000.0 | nM | - |
| CHEMBL3612837 | — | IC50 | = | 123000.0 | nM | - |