Assay Detail
ADMET
CHEMBL3614438
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Cytotoxicity against rat hepatocytes assessed as cell viability after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.15 | 4.60 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348475 | TARIQUIDAR | 3.0 | 1 | 4.60 |
| CHEMBL3613013 | — | — | 1 | 4.30 |
| CHEMBL3613016 | — | — | 1 | 4.30 |
| CHEMBL444075 | — | — | 1 | 4.30 |
| CHEMBL3613014 | — | — | 1 | 4.00 |
| CHEMBL3612988 | — | — | 1 | 4.00 |
| CHEMBL3612987 | — | — | 1 | 4.00 |
| CHEMBL3613017 | — | — | 1 | 4.00 |
| CHEMBL3613020 | — | — | 1 | 4.00 |
| CHEMBL3613021 | — | — | 1 | 4.00 |
| CHEMBL3613015 | — | — | 1 | - |
| CHEMBL3613011 | — | — | 1 | - |
| CHEMBL155285 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348475 | TARIQUIDAR | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3613013 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3613016 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL444075 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3613014 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3612988 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3612987 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3613017 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3613020 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3613021 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3613015 | — | Activity | - | — | - | |
| CHEMBL3613011 | — | Activity | - | — | - | |
| CHEMBL155285 | — | Activity | - | — | - |