Assay Detail
Binding
CHEMBL3614554
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Inhibition of human recombinant full length carbonic anhydrase 7 preincubated for 15 mins by stopped-flow CO2 hydration assay
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.79 | 8.62 |
| IC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3613775 | — | — | 1 | 8.62 |
| CHEMBL3613779 | — | — | 1 | 8.55 |
| CHEMBL3613778 | — | — | 1 | 8.51 |
| CHEMBL3613782 | — | — | 1 | 8.40 |
| CHEMBL3613783 | — | — | 1 | 8.07 |
| CHEMBL3613780 | — | — | 1 | 8.04 |
| CHEMBL3613777 | — | — | 1 | 6.09 |
| CHEMBL3613776 | — | — | 1 | 6.06 |
| CHEMBL3613781 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3613775 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL3613779 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL3613778 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL3613782 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3613783 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL3613780 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL3613777 | — | Ki | = | 819.0 | nM | 6.09 |
| CHEMBL3613776 | — | Ki | = | 878.0 | nM | 6.06 |
| CHEMBL3613781 | — | IC50 | > | 50000.0 | nM | - |