Assay Detail
Binding
CHEMBL3614931
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ABHD6 expressed in HEK293 cells assessed as reduction in glycerol production from 1-AG hydrolysis pre-incubated for 30 mins before 1-AG substrate addition and measured 90 mins post substrate addition by fluorescence method
14
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.60 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3613671 | — | — | 2 | 7.36 |
| CHEMBL3613162 | — | — | 2 | 7.14 |
| CHEMBL3613161 | — | — | 2 | 6.89 |
| CHEMBL3613003 | — | — | 2 | 6.67 |
| CHEMBL3613666 | — | — | 2 | 6.35 |
| CHEMBL3613668 | — | — | 2 | 6.06 |
| CHEMBL3401455 | — | — | 2 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3613671 | — | IC50 | = | 43.65 | nM | 7.36 |
| CHEMBL3613671 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3613162 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3613162 | — | IC50 | = | 74.13 | nM | 7.13 |
| CHEMBL3613161 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3613161 | — | IC50 | = | 131.83 | nM | 6.88 |
| CHEMBL3613003 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL3613003 | — | IC50 | = | 218.78 | nM | 6.66 |
| CHEMBL3613666 | — | IC50 | = | 446.68 | nM | 6.35 |
| CHEMBL3613666 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3613668 | — | IC50 | = | 870.96 | nM | 6.06 |
| CHEMBL3613668 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3401455 | — | IC50 | = | 1778.28 | nM | 5.75 |
| CHEMBL3401455 | — | IC50 | = | 1780.0 | nM | 5.75 |