Assay Detail
Binding
CHEMBL3614949
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Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compound dilution measured after 10 mins by HPLC method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.77 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | 4.0 | 1 | 7.88 |
| CHEMBL3613671 | — | — | 1 | 7.04 |
| CHEMBL3613003 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | IC50 | = | 13.18 | nM | 7.88 |
| CHEMBL3613671 | — | IC50 | = | 91.2 | nM | 7.04 |
| CHEMBL3613003 | — | IC50 | = | 4073.8 | nM | 5.39 |