Assay Detail
Binding
CHEMBL3614957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from MOR in guinea pig cerebellum membranes
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.56 | 9.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3613173 | — | — | 1 | 9.71 |
| CHEMBL3613172 | — | — | 1 | 9.64 |
| CHEMBL3613171 | — | — | 1 | 9.63 |
| CHEMBL3613174 | — | — | 1 | 9.55 |
| CHEMBL3613165 | — | — | 1 | 9.38 |
| CHEMBL490665 | NALFURAFINE HYDROCHLORIDE | 4.0 | 1 | 9.37 |
| CHEMBL3613164 | — | — | 1 | 9.29 |
| CHEMBL3613163 | — | — | 1 | 9.24 |
| CHEMBL3613166 | — | — | 1 | 8.57 |
| CHEMBL3613168 | — | — | 1 | 8.36 |
| CHEMBL3613280 | — | — | 1 | 7.94 |
| CHEMBL3613169 | — | — | 1 | 7.91 |
| CHEMBL3613167 | — | — | 1 | 7.86 |
| CHEMBL3613170 | — | — | 1 | 7.32 |
| CHEMBL3613175 | — | — | 1 | 7.32 |
| CHEMBL3613282 | — | — | 1 | 7.25 |
| CHEMBL3613281 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3613173 | — | Ki | = | 0.197 | nM | 9.71 |
| CHEMBL3613172 | — | Ki | = | 0.229 | nM | 9.64 |
| CHEMBL3613171 | — | Ki | = | 0.232 | nM | 9.63 |
| CHEMBL3613174 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL3613165 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL490665 | NALFURAFINE HYDROCHLORIDE | Ki | = | 0.431 | nM | 9.37 |
| CHEMBL3613164 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL3613163 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL3613166 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL3613168 | — | Ki | = | 4.36 | nM | 8.36 |
| CHEMBL3613280 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL3613169 | — | Ki | = | 12.2 | nM | 7.91 |
| CHEMBL3613167 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL3613170 | — | Ki | = | 47.6 | nM | 7.32 |
| CHEMBL3613175 | — | Ki | = | 47.9 | nM | 7.32 |
| CHEMBL3613282 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL3613281 | — | Ki | = | 59.6 | nM | 7.22 |