Assay Detail
Binding
CHEMBL3615232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-diprenorphine from zebrafish mu opioid receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Danio rerio |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, pharmacological evaluation and molecular dynamics of β-amino acids morphan-derivatives as novel ligands for opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 4.82 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.73 |
| CHEMBL3612241 | — | — | 1 | 5.08 |
| CHEMBL3612242 | — | — | 1 | 5.02 |
| CHEMBL3612243 | — | — | 1 | 4.90 |
| CHEMBL3612240 | — | — | 1 | 4.50 |
| CHEMBL3612238 | — | — | 1 | 4.45 |
| CHEMBL3612239 | — | — | 1 | 4.43 |
| CHEMBL3612245 | — | — | 1 | 4.12 |
| CHEMBL3612244 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | Ki | = | 187.4 | nM | 6.73 |
| CHEMBL3612241 | — | Ki | = | 8240.0 | nM | 5.08 |
| CHEMBL3612242 | — | Ki | = | 9520.0 | nM | 5.02 |
| CHEMBL3612243 | — | Ki | = | 12660.0 | nM | 4.90 |
| CHEMBL3612240 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL3612238 | — | Ki | = | 35280.0 | nM | 4.45 |
| CHEMBL3612239 | — | Ki | = | 36980.0 | nM | 4.43 |
| CHEMBL3612245 | — | Ki | = | 75780.0 | nM | 4.12 |
| CHEMBL3612244 | — | Ki | = | 78020.0 | nM | 4.11 |