Assay Detail
Binding
CHEMBL3615732
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Inhibition of human recombinant carbonic anhydrase-1 expressed in Escherichia coli incubated for 15 mins by stopped-flow CO2 hydration assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.13 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3354132 | — | — | 1 | 7.17 |
| CHEMBL3354135 | — | — | 1 | 7.08 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3354132 | — | Ki | = | 67.1 | nM | 7.17 |
| CHEMBL3354135 | — | Ki | = | 82.6 | nM | 7.08 |
| CHEMBL218490 | DORZOLAMIDE | Ki | > | 50000.0 | nM | - |