Assay Detail
Binding
CHEMBL3616083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of epidermal growth factor receptor kinase (unknown origin) using [33P]-ATP after 20 to 30 mins by radiometric assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular design and synthesis of certain new quinoline derivatives having potential anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.06 | 10.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29197 | — | — | 1 | 10.54 |
| CHEMBL3613702 | — | — | 1 | 10.43 |
| CHEMBL91867 | — | — | 1 | 9.60 |
| CHEMBL31965 | CANERTINIB | 3.0 | 1 | 9.10 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 8.70 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 7.97 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.58 |
| CHEMBL220037 | — | — | 1 | 7.52 |
| CHEMBL607707 | PELITINIB | 2.0 | 1 | 7.41 |
| CHEMBL180022 | NERATINIB | 4.0 | 1 | 7.04 |
| CHEMBL115187 | — | — | 1 | 6.89 |
| CHEMBL157128 | — | — | 1 | 6.82 |
| CHEMBL113900 | — | — | 1 | 6.60 |
| CHEMBL30973 | — | — | 1 | 6.51 |
| CHEMBL441279 | — | — | 1 | 6.48 |
| CHEMBL327023 | — | — | 1 | 6.26 |
| CHEMBL281300 | — | — | 1 | 6.23 |
| CHEMBL323630 | — | — | 1 | 6.19 |
| CHEMBL115440 | — | — | 1 | 6.03 |
| CHEMBL283682 | — | — | 1 | 6.03 |
| CHEMBL114593 | — | — | 1 | 6.02 |
| CHEMBL326811 | — | — | 1 | 5.79 |
| CHEMBL118000 | — | — | 1 | 5.64 |
| CHEMBL114392 | — | — | 1 | 5.57 |
| CHEMBL3613695 | — | — | 1 | 5.32 |
| CHEMBL3613691 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29197 | — | IC50 | = | 0.029 | nM | 10.54 |
| CHEMBL3613702 | — | IC50 | = | 0.037 | nM | 10.43 |
| CHEMBL91867 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL31965 | CANERTINIB | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL554 | LAPATINIB | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL939 | GEFITINIB | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL220037 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL607707 | PELITINIB | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL180022 | NERATINIB | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL115187 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL157128 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL113900 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL30973 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL441279 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL327023 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL281300 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL323630 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL115440 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL283682 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL114593 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL326811 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL118000 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL114392 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3613695 | — | IC50 | = | 4824.0 | nM | 5.32 |
| CHEMBL3613691 | — | IC50 | = | 5283.0 | nM | 5.28 |