Assay Detail
Functional
CHEMBL3616149
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Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl)benzo[d]thiazol-2-yl)urea as anticancer agents with low toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.17 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3612316 | — | — | 1 | 6.75 |
| CHEMBL3612315 | — | — | 1 | 6.62 |
| CHEMBL3612322 | — | — | 1 | 6.60 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.54 |
| CHEMBL3612310 | — | — | 1 | 6.52 |
| CHEMBL3612312 | — | — | 1 | 6.51 |
| CHEMBL1615189 | — | — | 1 | 6.36 |
| CHEMBL3612309 | — | — | 1 | 6.33 |
| CHEMBL3612311 | — | — | 1 | 6.28 |
| CHEMBL3612314 | — | — | 1 | 6.27 |
| CHEMBL3612320 | — | — | 1 | 6.27 |
| CHEMBL3612321 | — | — | 1 | 6.24 |
| CHEMBL3612313 | — | — | 1 | 6.21 |
| CHEMBL3612319 | — | — | 1 | 6.19 |
| CHEMBL3612199 | — | — | 1 | 6.06 |
| CHEMBL3612197 | — | — | 1 | 6.04 |
| CHEMBL3612194 | — | — | 1 | 5.81 |
| CHEMBL3612196 | — | — | 1 | 5.76 |
| CHEMBL3612198 | — | — | 1 | 5.53 |
| CHEMBL3612318 | — | — | 1 | 5.34 |
| CHEMBL3612193 | — | — | 1 | 5.24 |
| CHEMBL3612195 | — | — | 1 | - |
| CHEMBL3612317 | — | — | 1 | - |
| CHEMBL3612192 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3612316 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3612315 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3612322 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3612310 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3612312 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1615189 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3612309 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3612311 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3612314 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3612320 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3612321 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3612313 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3612319 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3612199 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3612197 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3612194 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL3612196 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL3612198 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL3612318 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL3612193 | — | IC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL3612195 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3612317 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3612192 | — | IC50 | > | 20000.0 | nM | - |